The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity
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چکیده
منابع مشابه
Letter by El-Battrawy et al Regarding Article, "The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity".
RATIONALE Genome-wide association studies previously identified an association of rs9388451 at chromosome 6q22.3 (near HEY2) with Brugada syndrome. The causal gene and underlying mechanism remain unresolved. OBJECTIVE We used an integrative approach entailing transcriptomic studies in human hearts and electrophysiological studies in Hey2+/- (Hey2 heterozygous knockout) mice to dissect the und...
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Darouna Kattygnarath, PharmD; Svetlana Maugenre, BS; Nathalie Neyroud, PhD; Elise Balse, PhD; Carole Ichai, MD; Isabelle Denjoy, MD, PhD; Gilles Dilanian, BS; Raphaël P. Martins, MD; Véronique Fressart, MD, PhD; Myriam Berthet, BS; Jean Jacques Schott, PhD; Antoine Leenhardt, MD; Vincent Probst, MD, PhD; Hervé Le Marec, MD, PhD; Bernard Hainque, PharmD, PhD; Alain Coulombe, PhD; Stéphane N. Hat...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2017
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.117.310959